Scientific Agent Skills
A research-grade skill set used by over 160,000 scientists for literature review, analysis, and scientific writing tasks.
by AgentVoltv1.0.0Published 1y ago1 install
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Before & after
Same prompt, same agent — the only difference is the skill.
Prompt“Find papers on CRISPR safety outcomes and synthesize findings.”
Beforegeneric AI agent
You can search academic databases like PubMed or Google Scholar for papers on that topic. Once you find relevant papers, you'll want to read abstracts, identify the most useful ones, and then synthesize the key findings across them. Taking structured notes on methodology, sample sizes, and conclusions will help. You might organize your synthesis by theme. Citation formatting is important for academic work. Would you like me to help you search for papers or guide you through organizing your findings?
Afterwith Scientific Agent Skills
RESEARCH SYNTHESIS: CRISPR Safety Outcomes (structured workflow)
LITERATURE SEARCH PROTOCOL:
Query strategy: ("CRISPR gene therapy" OR "CRISPR-Cas9") AND ("adverse events" OR "safety" OR "off-target") AND (2023 OR 2024 OR 2025). Databases: PubMed (prioritize), bioRxiv preprints, Google Scholar. Filter: clinical trials + recent systematic reviews only (exclude opinion pieces). Result: 24 papers identified, 8 meet inclusion criteria (randomized trials, N>50, peer-reviewed).
DATA EXTRACTION FRAMEWORK (per paper):
Author + Year | Trial Type | N Subjects | CRISPR Method | Primary Outcome | Safety Events Reported | Off-Target Rate | Funding Source | Confidence Grade
SYNTHESIS BY THEME:
THEME 1: OFF-TARGET EFFECTS (6 papers)
Consensus: In vivo off-target rate ranges 0.3-2.1% genome-wide (depends on Cas9 variant). Ex vivo (edited cells before transplant): near-zero off-target detectable. Implication: Ex vivo CRISPR safer for current deployment (immunotherapy, sickle cell trials show no off-target events in 340-subject meta-analysis).
THEME 2: IMMUNE RESPONSE (4 papers)
Consensus: Pre-existing anti-Cas9 antibodies present in 50-80% of human population. Does not prevent initial efficacy but may shorten durability. Re-dosing complications unclear in small N trials.
THEME 3: DELIVERY TOXICITY (5 papers)
Consensus: AAV vector toxicity dominates adverse event profile, not CRISPR itself. Dose-dependent liver enzyme elevation observed. LNP-mRNA delivery shows better safety profile but lower editing efficiency.
KEY GAPS: No long-term follow-up data beyond 3 years. Off-target measurement relies on computational prediction + shallow sequencing (undetected variants possible).
CITATION FORMAT (Vancouver style):
1. Smith J, Jones K, et al. Off-target CRISPR editing in vivo. Nature Biotech. 2024;42(3):234-241.
CONCLUSION (evidence grade: moderate, not advice):
CRISPR ex vivo therapies show acceptable safety profile for specific indications (blood disorders, immunotherapy). In vivo applications remain investigational. Regulatory approval remains cautious—require 5+ year follow-up data.About this skill
name: scientific-agent-skills description: Use when A research-grade skill set used by over 160,000 scientists for literature review, analysis, and scientific writing tasks.
Scientific Agent Skills
Scientific Agent Skills packages research-grade workflows such as literature search, data analysis conventions, and citation handling into Claude skills built specifically for scientific work.
What you get
- Public GitHub repo with the full skill collection and install instructions.
Customize your output
- Select only the specific research skills relevant to your field.
Example output
Shown in the channel's ranked skill rundown as the number 4 most-starred Claude Skill.
Best for
Researchers, scientists, and academic teams.
SKILL.md preview
SKILL.md
---
name: scientific-agent-skills
description: Use this skill for research-grade scientific work such as literature review, structured data analysis, and citation-managed scientific writing.
version: 1.0.0
category: Research & Data / Science
author: AgentVolt
license: proprietary
tags:
- research-data
- science
- standard
---
# Scientific Agent Skills
Packages research-grade workflows for literature review, structured data analysis, and citation-managed scientific writing.
## When to use
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