Bio-Research (Preclinical R&D)
Preclinical R&D toolkit connecting Claude to 11 external data sources (literature, chemistry, clinical trials, genomics) with 5 analysis skills.
Before & after
Same prompt, same agent — the only difference is the skill.
I can help you research that. We should look at recent published literature on CRISPR off-target effects, check some clinical trial databases to see what's being tested, maybe look at preprints if there's cutting-edge work. There might be some chemistry databases that catalog off-target binding sites too. We could search PubMed for reviews, look at what's in bioRxiv, check what trials are registered. It would be good to synthesize what we find into a summary. Do you have a specific CRISPR platform in mind, or are you looking at effects broadly? Any particular tissue or indication you care about?
OFF-TARGET CRISPR EFFECTS: SYNTHESIS FROM 11 SOURCES LITERATURE LAYER → PubMed/NLM: 127 papers on CRISPR off-target toxicity (2024-2026). Top 8 ranked by relevance. → bioRxiv/medRxiv: 19 recent preprints; 3 flagged as high-impact (single-cell assay methods). → Consensus (peer-reviewed synthesis): "Off-target cleavage rates vary 100-fold by gRNA sequence; predicted by thermodynamic models with 76% accuracy." CHEMISTRY + GENOMICS → ChEMBL: 43 compounds targeting PAM-adjacent sequences; structural similarities to endogenous genomic sites mapped. → Open Targets: Top 12 off-target risk genes (VEGFA, TP53, BRCA1 region homologies). CLINICAL EVIDENCE → ClinicalTrials.gov: 7 active trials with off-target monitoring protocols. Lentiviral delivery shows 2.3x higher off-target rate vs adeno-associated virus. → Benchling (lab data): integration-site sequencing from 4 clinical programs shows chromosomal rearrangements in 3 of 240 cells (1.25% event rate). ACTION: Off-target risk lowest with chemical-modified gRNAs + mRNA delivery; highest with lentiviral. Recommend validating new targets via single-cell assay (scvi-tools pipeline available).
About this skill
name: kw-bio-research description: Use when preclinical R&D toolkit connecting Claude to 11 external data sources (literature, chemistry, clinical trials, genomics) with 5 analysis skills.
Bio-Research (Preclinical R&D)
Anthropic's Bio-Research plugin consolidates 11 MCP server integrations and 5 analysis skills into one bundle for life sciences researchers. Data sources include PubMed and NLM biomedical literature, bioRxiv/medRxiv preprints, Consensus for peer-reviewed synthesis, Wiley journals, Sage Bionetworks for research data management, ChEMBL for bioactive drug-like compounds, Open Targets for target discovery and prioritization, ClinicalTrials.gov, BioRender for scientific illustration, Owkin for AI in histopathology and drug discovery, and Benchling for lab data management. Analysis skills cover literature review search, single-cell (scRNA-seq QC via scvi-tools), sequencing pipelines (GEO/SRA + nf-core), drug discovery, and research strategy.
What you get
- 11 connected MCPs (PubMed/NLM, bioRxiv/medRxiv, Consensus, Wiley, Sage Bionetworks, ChEMBL, Open Targets, ClinicalTrials.gov, BioRender, Owkin, Benchling)
- 5 skills (literature review search, single-cell analysis, sequencing pipeline, drug discovery, research strategy)
- scRNA-seq QC via scvi-tools
- GEO/SRA download + nf-core pipelines
Customize your output
- Data source: literature, preprints, chemical DB, clinical trials, drug targets, lab platform
- Analysis skill: literature review, single-cell, sequencing pipeline, drug discovery, research strategy
Example output
For a target-prioritization ask, Claude queries Open Targets for evidence tiers, pulls the top PubMed and bioRxiv papers per target, checks ChEMBL for existing chemical matter, and ranks candidates with evidence citations.
Best for
Preclinical life-sciences researchers and computational biologists working on target ID, single-cell analysis, and drug discovery
SKILL.md preview
---
name: kw-bio-research
description: Use this skill for preclinical R&D work that requires literature search, chemistry, clinical trial, or genomics data across connected life-sciences tools.
version: 1.0.0
category: Life Sciences
author: AgentVolt
license: proprietary
tags:
- life-sciences
- p3
---
# Bio-Research (Preclinical R&D)
Coordinates literature search, compound data, target discovery, and clinical trial lookups across connected life-sciences data sources for preclinical work.
## When to use
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